Machine learning may enable bioengineering of the most abundant enzyme on the planet
Credit: Pixabay/CC0 Public Domain

A Newcastle University study has for the first time shown that machine learning can predict the biological properties of the most abundant enzyme on Earth—Rubisco.

Rubisco (Ribulose-1,5-bisphosphate carboxylase/oxygenase) is responsible for providing carbon for almost all life on Earth. Rubisco functions by converting atmospheric CO2 from the Earth’s atmosphere to organic carbon matter, which is essential to sustain most life on Earth.

For some time now, natural variation has been observed among Rubisco proteins of land plants and modeling studies have shown that transplanting Rubisco proteins with certain functional properties can increase the amount of atmospheric CO2 crop plants can uptake and store.

Study lead author, Wasim Iqbal, a Ph.D. researcher at Newcastle University’s School of Natural and Environmental Sciences, part of Dr. Maxim Kapralov’s group, developed a machine learning tool which can predict the performance properties of numerous land plant Rubisco proteins with surprisingly good accuracy. The hope is that this tool will enable the hunt for a ‘supercharged’ Rubisco protein that can be bioengineered into major crops such as wheat.

Published in the Journal Of Experimental Botany, the study presents a useful tool for screening and predicting plant Rubisco kinetics for engineering efforts as well as for fundamental studies on Rubisco evolution and adaptation. Screening the natural diversity of Rubisco kinetics is the main strategy used to find better Rubiscos for crop engineering efforts.

Wasim says that their “study will have huge implications for climate models and bioengineering crops.”

“This study provides plant biologists with a pre-screening tool for highlighting Rubisco species exhibiting better kinetics for crop engineering efforts.”

“The machine learning tool can be used to improve the accuracy of global photosynthesis estimates. The Rubisco performance properties our model predicts are compatible with Earth system models (ESM) used by climate scientists. Currently, ESMs use a single set of Rubisco properties from the same species (or sometimes a handful) for estimating photosynthesis at the ecosystem scale. Our machine learning tool could provide predictions for most land plants improving the accuracy of ESMs.”

Next steps of this work include isolating the best Rubisco proteins identified from predictions in the lab and attempting to bioengineer a plant species with a foreign Rubisco protein. More information: Wasim A Iqbal et al, Predicting plant Rubisco kinetics from RbcL sequence data using machine learning, Journal of Experimental Botany (2022). DOI: 10.1093/jxb/erac368 Journal information: Journal of Experimental Botany,

Provided by Newcastle University Citation: Machine learning may enable bioengineering of the most abundant enzyme on the planet (2022, September 30) retrieved 30 September 2022 from https://phys.org/news/2022-09-machine-enable-bioengineering-abundant-enzyme.html This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

NEWS RELATED

500M WhatsApp mobile numbers up for sale on the dark web

The seller claims to have data of users from over 84 countries, including US, UK, India, Egypt, Mexico and Russia.

View more: 500M WhatsApp mobile numbers up for sale on the dark web

Financial services increasingly targeted for API-based cyber attacks

API-based attacks are sharply on the rise, as cyber criminals take aim at the financial services industry, according to a new report from Akamai.

View more: Financial services increasingly targeted for API-based cyber attacks

Acer Swift 5 (2022) review: A solid all-rounder

Much welcomed updates The Swift 5 is Acer’s fanciest ultraportable notebook that purports to blend style, performance, and portability. The newest edition gets Intel’s latest Alder Lake processors, a new display, and some design tweaks and other updates. And on paper, it looks like the ultraportable notebook to have. ...

View more: Acer Swift 5 (2022) review: A solid all-rounder

Last Chance for These 29 Cyber Monday Doodads on Amazon

The hours are dwindling on Cyber Monday, but you can still find some fun little trinkets on sale.

View more: Last Chance for These 29 Cyber Monday Doodads on Amazon

Best Target Cyber Monday Sales: Final Hours to Score These 27+ Deals

You only have a few hours left to snatch up these TVs, gaming consoles, kitchen appliances and more -- for a bargain.

View more: Best Target Cyber Monday Sales: Final Hours to Score These 27+ Deals

AWS releases Wickr, its encrypted messaging service for enterprises

The release of the enterprise version of the encrypted messaging service is designed to allow secure collaboration across messaging, voice, video and file sharing.

View more: AWS releases Wickr, its encrypted messaging service for enterprises

Samsung Galaxy S23, Galaxy S23 Plus appear on FCC

Samsung is moving on to bring the Samsung Galaxy S23 series. The leaks are popping out everywhere and the company is already doing the preparations for the release. One of the steps is going through multiple certification bodies across the world. Today, the Galaxy S23 and the Galaxy S23+ were ...

View more: Samsung Galaxy S23, Galaxy S23 Plus appear on FCC

Ant-Man and the Wasp: Quantumania: Release date, cast, trailers, & everything we know

Ant-Man and the Wasp: Quantumania will kick off the MCU’s Phase 5, with the sequel set to premiere on February 17th, 2023. The third installment in the Ant-Man story should have higher stakes than its predecessors, delivering a story that will have major consequences for the future of the ...

View more: Ant-Man and the Wasp: Quantumania: Release date, cast, trailers, & everything we know

Musk attacks Apple over Twitter ads, store

Samsung Galaxy Z Flip4 Maison Margiela will cost $1688

Oppo Find N2 To Feature Samsung E6 OLED Display With 120Hz Refresh Rate

Elon Musk: Apple ‘Threatened to Withhold Twitter’ From App Store

Apple iPhone 15: New Camera System with Sony Sensor to Bring Better Dynamic Range, No Overexposed Shots

Apple iPhone 15 said to use Sony's new image sensor

Tesla is working on a redesign of the Model 3

Noise eyes overseas market for its wearables, open to fund raising

Startups’ office leasing remains robust, to account for one-third of activity in 2022

IT pro looking to jump jobs? Temper down your expectations

Tech adoption cycle in India still has good legroom: Salseforce CEO

Flipkart may go in for $700 million esop buyback

OTHER NEWS

Breaking thailand news, thai news, thailand news Verified News Story Network