Our college football betting writer brings you his best betting picks and predictions for the matchup between No. 15 Notre Dame and No. 6 USC, which is live Saturday on ABC at 7:30 p.m. ET.

In the regular-season finale for both teams, the Trojans are hoping an 11th win could possibly squeeze them into the College Football Playoff. The resurgent Fighting Irish need to pull an upset to have a chance at playing in a New Year’s Six bowl game.

Notre Dame vs. USC predictions

• Notre Dame to cover +5.5 spread @ -117 via Caesars Sportsbook

• Over 64.5 total points to be scored @ -117 via Caesars Sportsbook

• Caleb Williams to run for more than 0.5 touchdowns @ +120 via Caesars Sportsbook

Notre Dame vs. USC predictions: College football picks and odds

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Notre Dame vs. USC predictions: College football picks and odds

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Notre Dame vs. USC predictions: College football picks and odds

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Notre Dame vs. USC predictions: College football picks and odds

Drew Pyne #10 of the Notre Dame Fighting Irish

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Notre Dame vs. USC picks and analysis

The Trojans have enjoyed a terrific first season under coach Lincoln Riley, bouncing back from last season’s 4-8 record to become a national powerhouse once again. The Fighting Irish, also under a first-year coach in Marcus Freeman, has recovered from an 0-2 start to win eight of nine heading into their 93rd all-time meeting with USC.

Notre Dame +5.5

Let’s start by pointing out that Notre Dame isn’t just winning games. It’s dominating the competition. Last week’s 44-0 romp over Boston College was obviously a one-sided affair, but the Fighting Irish’s last two games against ranked opponents were also blowouts – wins over Syracuse and Clemson by a combined 38 points.

This clearly is not the same Notre Dame team that scored 10 points against Ohio State in its season opener and then lost to Marshall one week later. The Irish have scored at least 35 points in every game during their current five-game winning streak, and the Trojans’ defense – which ranks only 65th nationally, allowing 26.3 points per game – is not going to be the team to slow them down.

USC will need to refocus after last week’s emotional 48-45 rivalry win over UCLA. This is an important game for the playoff-hopeful Trojans. They have only beaten Notre Dame three times in the last 11 matchups.

Pick: Notre Dame +5.5 @ -117 with Caesars Sportsbook

Notre Dame vs. USC predictions: College football picks and odds

Caleb Williams #13 of the USC Trojans runs the ball against Mo Osling III #7 of the UCLA Bruins

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Over 64.5 total points

Notre Dame and USC have not played a lot of low-scoring games in recent weeks. The Fighting Irish and Trojans both have seen their last five games go over the projected total with Notre Dame’s last five games averaging 57.6 total points and USC’s last five contests averaging a whopping 81.6 combined points.

Trojans quarterback Caleb Williams has one final chance to make a Heisman statement, so don’t be surprised if Riley gives him every opportunity to shine in the regular-season finale. He certainly did plenty of shining against UCLA, passing for 470 yards with three total touchdowns last weekend. So, with Williams airing it out and Notre Dame facing the inconsistent USC defense, look for points to be plentiful.

Pick: Over 64.5 total points scored @ -117 with Caesars Sportsbook

Caleb Williams anytime touchdown scorer +120

The USC quarterback has scored four rushing touchdowns in his last three games – and all of those scores have come in the first half. The Trojans clearly trust Williams as a runner to get them an early lead, and he has been validating their trust in recent weeks.

Those four touchdowns have not been long, fluky runs, either. They have covered 1, 2, 4, and 6 yards, indicating that when USC gets close to the end zone, particularly early in games, that the coaching staff likes to call Williams’ number.

In all, six of Williams’ seven rushing touchdowns have come at home – and all seven have come in the first half of games – so look for Williams to plunge into the end zone shortly into Saturday’s contest for an easy payday.

Pick: Caleb Williams over 0.5 rushing TDs @ +120 with Caesars Sportsbook

Notre Dame vs. USC odds

Odds courtesy of Caesars Sportsbook. Correct at time of publishing and subject to change.

Team Spread Moneyline Total Points 64.5
Notre Dame (+5.5) -117 +165 Over -117
USC (-5.5) +117 -234 Under -117

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